carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

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Chemical Name:carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester
CAS No.:220377-90-2
Molecular Formula:C₃₉H₄₂ClN₃O₅S
Molecular Weight:700.299
Hs Code.:

Synonyms:carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

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Chemical Property of carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

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Technology Process of carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

There total 7 articles about carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 204857-35-2
N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

: 184030-88-4
4-[1-(Triphenylmethyl)imidazol-4-yl]butan-1-al

: 220377-90-2
carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

Guidance literature:: N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

4-[1-(Triphenylmethyl)imidazol-4-yl]butan-1-al; In tetrahydrofuran; at -78 - 20 ℃; for 2h;
DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

: 33016-47-6
(1-tritylimidazol-4-yl)carboxaldehyde

: 220377-90-2
carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -20 °C

1.2: 42 percent / tetrahydrofuran / 18 h / 20 °C

2.1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 20 °C / atmospheric pressure

3.1: 91 percent / 2M HCl / acetone / 20 h / 20 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 °C

4.2: 48 percent / tetrahydrofuran / 2 h / -78 - 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

: 406225-21-6
(Z)-4-(3-(1,3-dioxolan-2-yl)prop-1-enyl)-1-trityl-1H-imidazole

: 220377-90-2
carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 20 °C / atmospheric pressure

2.1: 91 percent / 2M HCl / acetone / 20 h / 20 °C

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 48 percent / tetrahydrofuran / 2 h / -78 - 20 °C

With hydrogenchloride; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0968-0896(01)00295-4