2-Benzyloxy-6-methylaniline

Base Information

• Chemical Name: 2-Benzyloxy-6-methylaniline
• CAS No.: 883107-58-2
• Molecular Formula: C14H15 N O
• Molecular Weight: 213.279
• DSSTox Substance ID: DTXSID40376599
• Wikidata: Q72494950
• Mol file: 883107-58-2.mol

Synonyms:2-BENZYLOXY-6-METHYLANILINE;883107-58-2;2-(BENZYLOXY)-6-METHYLANILINE;2-methyl-6-phenylmethoxyaniline;Benzenamine,2-methyl-6-(phenylmethoxy)-;2-Benzyloxy-6-methylphenylamine;SCHEMBL648673;2-benzyloxy-6-methyl-phenylamine;DTXSID40376599;RXZGJDHFSKTGHK-UHFFFAOYSA-N;CS-0088014;FT-0730919;EN300-1296172

Chemical Property of 2-Benzyloxy-6-methylaniline

Chemical Property:

• Boiling Point: 362℃
• Flash Point: 178℃
• PSA: 35.25000
• Density: 1.106
• LogP: 3.73740
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 213.115364102
• Heavy Atom Count: 16
• Complexity: 201

Purity/Quality:

97% ^*data from raw suppliers

2-Benzyloxy-6-methyl-phenylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)OCC2=CC=CC=C2)N

Technology Process of 2-Benzyloxy-6-methylaniline

There total 3 articles about 2-Benzyloxy-6-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(benzyloxy)-3-methyl-2-nitrobenzene (61535-21-5) → 2-(benzyloxy)-6-methylbenzenamine (883107-58-2)

Guidance literature:

1-(benzyloxy)-3-methyl-2-nitrobenzene; With iron; ammonium chloride; In methanol; water; at 95 ℃; for 16h;

With sodium hydroxide; In water;

Reference yield:

benzyl bromide (100-39-0) → 2-(benzyloxy)-6-methylbenzenamine (883107-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: iron; ammonium chloride / methanol; water / 1 h / 95 °C

With iron; potassium carbonate; ammonium chloride; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

3-methyl-2-nitrophenol (4920-77-8) → 2-(benzyloxy)-6-methylbenzenamine (883107-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: iron; ammonium chloride / methanol; water / 1 h / 95 °C

With iron; potassium carbonate; ammonium chloride; In methanol; water; N,N-dimethyl-formamide;

upstream raw materials:

1-(benzyloxy)-3-methyl-2-nitrobenzene

benzyl bromide

3-methyl-2-nitrophenol

Downstream raw materials:

2-(benzyloxy)-4-bromo-6-methylbenzenamine

Refernces

• 1、 -. "CGRP antagonists". Page/Page column 13. . Retrieved 2010/11/26.