N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Base Information

Chemical Name:N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide
CAS No.:1351373-54-0
Molecular Formula:C₂₂H₂₃N₅O₃
Molecular Weight:405.456
Hs Code.:

Synonyms:N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

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Chemical Property of N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

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Technology Process of N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

There total 5 articles about N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1263422-44-1
4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

: 107-19-7
propargyl alcohol

: 1351373-54-0
N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 80 ℃; for 2h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 1351373-54-0
N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / 23 - 60 °C / Inert atmosphere

2: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 60 h / 40 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere

4: piperidine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 80 °C / Microwave irradiation; Inert atmosphere

With piperidine; potassium phosphate; N-iodo-succinimide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 860173-33-7
4-(cyclopropylaminocarbonyl)phenylboronic acid pinacol ester

: 1351373-54-0
N-cyclopropyl-4-{8-[(3-hydroxypropyl)amino]-6-(3-hydroxyprop-1-yn-1-yl)imidazo[1,2-a]pyrazin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 60 h / 40 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere

3: piperidine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 80 °C / Microwave irradiation; Inert atmosphere

With piperidine; potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide;