4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

Base Information

Chemical Name:4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide
CAS No.:1263422-44-1
Molecular Formula:C₁₉H₂₀BrN₅O₂
Molecular Weight:430.304
Hs Code.:

Synonyms:4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

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Technology Process of 4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

There total 5 articles about 4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1351373-55-1
N-cyclopropyl-4-(6,8-dibromo-imidazo[1,2-a]pyrazin-3-yl)-benzamide

: 156-87-6
propan-1-ol-3-amine

: 1263422-44-1
4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

Guidance literature:: In N,N-dimethyl-formamide; at 40 ℃; for 6h; Inert atmosphere;

Reference yield: 92.0%

: 1263422-44-1
4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

Guidance literature:

Reference yield:

: 63744-22-9
6,8-dibromoimidazo[1,2-a]pyrazine

: 1263422-44-1
4-{6-bromo-8-[(3-hydroxypropyl)amino]imidazo[1,2-a]pyrazin-3-yl}-N-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide / 18 h / 23 - 60 °C / Inert atmosphere

2: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 60 h / 40 °C / Inert atmosphere

3: N,N-dimethyl-formamide / 6 h / 40 °C / Inert atmosphere

With potassium phosphate; N-iodo-succinimide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;