N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

Base Information

Chemical Name:N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester
CAS No.:618095-52-6
Molecular Formula:C₂₁H₂₇N₃O₁₀
Molecular Weight:481.459
Hs Code.:

N<sup>α</sup>-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

Synonyms:N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

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Chemical Property of N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

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Technology Process of N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

There total 4 articles about N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 107-14-2
chloroacetonitrile

: 618095-51-5
N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid

: 618095-52-6
N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1021/jo035774n

Reference yield:

: 1016-58-6
6-nitroveratryl alcohol

: 618095-52-6
N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 20 °C

2.1: p-dimethoxybenzene; trifluoroacetic acid / CH₂Cl₂ / 12 h / 20 °C

2.2: 64 percent / 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; triethylamine / dimethylformamide / 3 h / 20 °C

3.1: 65 percent / triethylamine / acetonitrile / 12 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; acetonitrile;
DOI:10.1021/jo035774n

Reference yield:

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: 618095-52-6
N^α-(tert-butoxycarbonyl)-γ-(6-nitroveratryl)glutamic acid cyanomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82 percent / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 20 °C

2.1: p-dimethoxybenzene; trifluoroacetic acid / CH₂Cl₂ / 12 h / 20 °C

2.2: 64 percent / 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile; triethylamine / dimethylformamide / 3 h / 20 °C

3.1: 65 percent / triethylamine / acetonitrile / 12 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 1,4-dimethoxybezene; In dichloromethane; acetonitrile;
DOI:10.1021/jo035774n