2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

Base Information

Chemical Name:2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide
CAS No.:1333327-12-0
Molecular Formula:C₁₆H₁₉BrN₂O₇
Molecular Weight:431.24
Hs Code.:

Synonyms:2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

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Technology Process of 2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

There total 1 articles about 2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: 623-33-6
glycine ethyl ester hydrochloride

: 151603-30-4
2-bromobenzene-1,3-dicarboxylic acid dichloride

: 1010118-03-2
2-bromo-N,N'-bis(2-oxo-2-ethoxyethyl)isophthalamide

: 1333327-12-0
2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

: 1333327-15-3
2-bromo-N,N'-bis(1-hydroxymethyl-2-oxo-2-methoxyethyl)isophthalamide

Guidance literature:: With triethylamine; In dichloromethane; at -15 - 20 ℃; for 12h;
DOI:10.1039/c1dt10369e

Reference yield: 70.0%

: 1333327-12-0
2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

: 1333327-13-1
2-bromo-3-(4-methoxycarbonyloxazolin-2-yl)-N-(2-oxo-2-ethoxyethyl)benzamide

Guidance literature:: 2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;

With potassium carbonate; In dichloromethane; at -78 - 20 ℃; for 1h;
DOI:10.1039/c1dt10369e

Reference yield:

: 1333327-12-0
2-bromo-N-(1-hydroxymethyl-2-oxo-2-methoxyethyl)-N'-(2-oxo-2-ethoxyethyl)isophthalamide

: 1333327-14-2
2-bromo-3-(4-methoxycarbonyloxazol-2-yl)-N-(2-oxo-2-ethoxyethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0 - 20 °C

With Bromotrichloromethane; diethylamino-sulfur trifluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1039/c1dt10369e