ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Base Information

Chemical Name:ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate
CAS No.:1353654-08-6
Molecular Formula:C₂₃H₃₈O₃Si
Molecular Weight:390.638
Hs Code.:

Synonyms:ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Suppliers and Price of ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

There total 8 articles about ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-7-phenylhept-2-en-1-ol

: 1353654-08-6
ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium(IV) isopropylate; diethyl (2S,3S)-tartrate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

1.2: 12 h / -20 °C

2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 3 h / 0 °C

3.1: pyridine / dichloromethane / 0 - 20 °C

4.1: 1H-imidazole / dichloromethane / 0.08 h / 0 °C

4.2: 1 h / 20 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / -78 °C

6.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2.75 h / -78 °C

7.1: benzene / 2 h / Reflux

With pyridine; 1H-imidazole; titanium(IV) isopropylate; oxalyl dichloride; diethyl (2S,3S)-tartrate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene; benzene; 1.1: Sharpless asymmetric epoxidation / 1.2: Sharpless asymmetric epoxidation / 6.1: Swern oxidation / 7.1: Wittig reaction;
DOI:10.1055/s-0030-1260214

Reference yield:

: [(2R,3R)-3-(4-phenylbutyl)oxiran-2-yl]methanol

: 1353654-08-6
ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 3 h / 0 °C

2.1: pyridine / dichloromethane / 0 - 20 °C

3.1: 1H-imidazole / dichloromethane / 0.08 h / 0 °C

3.2: 1 h / 20 °C

4.1: diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / -78 °C

5.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2.75 h / -78 °C

6.1: benzene / 2 h / Reflux

With pyridine; 1H-imidazole; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; toluene; benzene; 5.1: Swern oxidation / 6.1: Wittig reaction;
DOI:10.1055/s-0030-1260214

Reference yield:

: 1353654-15-5
(3R)-3-hydroxy-7-phenylheptyl pivalate

: 1353654-08-6
ethyl (2E,5R)-5-{[tert-butyl(dimethyl)silyl]oxy}-9-phenylnon-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / dichloromethane / 0.08 h / 0 °C

1.2: 1 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / -78 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / 2.75 h / -78 °C

4.1: benzene / 2 h / Reflux

With 1H-imidazole; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; benzene; 3.1: Swern oxidation / 4.1: Wittig reaction;
DOI:10.1055/s-0030-1260214