5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

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Chemical Name:5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide
CAS No.:658085-52-0
Molecular Formula:C₁₈H₁₆F₂N₈O₃
Molecular Weight:430.374
Hs Code.:

Synonyms:5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

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Chemical Property of 5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

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Technology Process of 5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

There total 9 articles about 5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 658084-97-0
4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)-5-isopropylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid

: 658085-52-0
5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

Guidance literature:: With diphenylphosphoryl azide; triethylamine; In 1,4-dioxane; at 40 ℃; for 1h;

Reference yield:

: 639858-45-0
5-amino-2,4-difluorobenzoic acid

: 658085-52-0
5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.98 g / EDCI; HOBt; diisopropylethylamine / tetrahydrofuran / 6 h / 20 °C

2: 78 percent / dimethylformamide / 18 h / 25 °C

3: aq. NaOH / tetrahydrofuran / 27 h / 60 °C

4: Et₃N; diphenylphosphoryl azide / dioxane / 1.5 h / 40 °C

With sodium hydroxide; diphenylphosphoranyl azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm0501275

Reference yield:

: 651744-39-7
diethyl 1-amino-3-(propan-2-yl)-1H-pyrrole-2,4-dicarboxylate

: 658085-52-0
5-(6-(azidocarbonyl)-5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-ylamino)-2,4-difluoro-N-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / 6 h / 165 °C

2: POCl₃; Et₃N / toluene / 6 h / Heating

3: 78 percent / dimethylformamide / 18 h / 25 °C

4: aq. NaOH / tetrahydrofuran / 27 h / 60 °C

5: Et₃N; diphenylphosphoryl azide / dioxane / 1.5 h / 40 °C

With sodium hydroxide; diphenylphosphoranyl azide; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0501275