(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Base Information

Chemical Name:(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid
CAS No.:1092938-51-6
Molecular Formula:C₂₅H₃₀N₂O₅
Molecular Weight:438.524
Hs Code.:

Synonyms:(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

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Chemical Property of (6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

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Technology Process of (6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

There total 11 articles about (6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1092938-23-2
tert-butyl (6R)-6-{[6-cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoate

: 1092938-51-6
(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1092938-51-6
(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethylammonium chloride; potassium fluoride / dichloromethane; xylene / 15 h / 160 °C

2.1: ethanol / 0.17 h / 85 °C

2.2: 15 h / 85 °C

3.1: N,N-diethylaniline; trichlorophosphate / toluene / 37 h / 100 °C

4.1: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 1.5 h / Reflux; Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

8.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With potassium fluoride; N-Bromosuccinimide; hydrogen; N,N-dimethylammonium chloride; sodium carbonate; phosphazene base-P₄-tert-butyl; trifluoroacetic acid; N,N-diethylaniline; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene; acetonitrile; xylene;

Reference yield:

: 1073630-51-9
(2E,6R)-6-hydroxyhept-2-enoic acid tert.-butyl ester

: 1092938-51-6
(6R)-6-{[6-Cyclopentyl-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]oxy}heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

2: phosphazene base-P₄-tert-butyl / hexane; tetrahydrofuran / 2.66 h / -10 - 20 °C / Inert atmosphere

3: N-Bromosuccinimide / acetonitrile / 2 h / 20 °C / Inert atmosphere

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 1.5 h / Reflux; Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 760.05 Torr

6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With N-Bromosuccinimide; hydrogen; sodium carbonate; phosphazene base-P₄-tert-butyl; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; acetonitrile;