(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

Base Information

Chemical Name:(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine
CAS No.:122237-36-9
Molecular Formula:C₆H₁₃N*C₁₆H₂₂O₅
Molecular Weight:393.524
Hs Code.:

Synonyms:(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

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Chemical Property of (4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

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Technology Process of (4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

There total 4 articles about (4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 122237-33-6,122237-34-7
(4SR,5R)-4-(Benzyloxymethyl)-5-ethyl-2,2-dimethyl-1,3-dioxolane-4-carboxylic Acid

: 108-91-8,157973-60-9
cyclohexylamine

: 122237-36-9
(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

Guidance literature:: In diethyl ether; for 1h;

Reference yield:

: 2749-70-4
bis(benzyloxy)methane

: 122237-36-9
(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 0.5 h / 0 °C

2: 1.) n-BuLi, N,N-diisopropylamine / 1.) THF, hexane, 0 deg C, then -78 deg C, 30 min, 2.) -78 deg C, 30 min

3: 95 percent / 3N KOH / methanol; H₂O / 4 h / 80 °C

4: 48 percent / diethyl ether / 1 h

With potassium hydroxide; n-butyllithium; diisopropylamine; In methanol; diethyl ether; water;

Reference yield:

: 17482-09-6
benzyl iodomethyl ether

: 122237-36-9
(4S,5R)-4-Benzyloxymethyl-5-ethyl-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid; compound with cyclohexylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi, N,N-diisopropylamine / 1.) THF, hexane, 0 deg C, then -78 deg C, 30 min, 2.) -78 deg C, 30 min

2: 95 percent / 3N KOH / methanol; H₂O / 4 h / 80 °C

3: 48 percent / diethyl ether / 1 h

With potassium hydroxide; n-butyllithium; diisopropylamine; In methanol; diethyl ether; water;