methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate

Base Information

• Chemical Name: methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate
• CAS No.: 876126-21-5
• Molecular Formula: C₃₀H₃₂ClN₃O₆
• Molecular Weight: 566.054

Synonyms:methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate

Chemical Property of methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate

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Technology Process of methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate

There total 7 articles about methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethanaminium acetate + 4-piperidyl N-(2-biphenyl)carbamate (171722-92-2) → methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate (876126-21-5)

Guidance literature:

In dichloromethane; isopropyl alcohol; at 20 - 55 ℃; for 18h; Product distribution / selectivity; Heating / reflux;

Reference yield: 29.0%

methyl 4-Acryloylamino-5-chloro-2-methoxybenzoate (743461-60-1) + 1-benzyl-4-piperidylbiphenyl-2-ylcarbamate (171723-80-1) → methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate (876126-21-5)

Guidance literature:

In tetrahydrofuran; methanol; at 50 ℃; for 16h;

Reference yield: 29.0%

methyl 4-Acryloylamino-5-chloro-2-methoxybenzoate (743461-60-1) + 4-piperidyl N-(2-biphenyl)carbamate (171722-92-2) → methyl 4-{3-[4-(Biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-5-chloro-2-methoxybenzoate (876126-21-5)

Guidance literature:

In tetrahydrofuran; methanol; at 50 ℃; for 16h;

upstream raw materials:

methyl 4-Acryloylamino-5-chloro-2-methoxybenzoate

1-benzyl-4-piperidylbiphenyl-2-ylcarbamate

4-piperidyl N-(2-biphenyl)carbamate

methyl 4-amino-5-chloro-2-methoxybenzoate

Downstream raw materials:

biphenyl-2-ylcarbamic Acid 1-[2-(2-Chloro-4-hydroxymethyl-5-methoxy-phenylcarbamoyl)ethyl]piperidin-4-yl Ester

biphenyl-2-ylcarbamic Acid 1-[2-(4-{[(R)-2-(tert-Butyldimethylsilanyloxy)-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-2-chloro-5-methoxy-phenylcarbamoyl)ethyl]piperidin-4-yl Ester

biphenyl-2-ylcarbamic Acid 1-[2-(2-Chloro-4-formyl-5-methoxyphenylcarbamoyl)-ethyl]piperidin-4-yl Ester

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