tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

Base Information

Chemical Name:tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate
CAS No.:158214-23-4
Molecular Formula:C₂₁H₂₇N₃O₃
Molecular Weight:369.464
Hs Code.:

tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopenta<d>pyrimidin-5-yl)propyl>benzoate

Synonyms:tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

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Technology Process of tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

There total 8 articles about tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.4%

: 50-01-1
guanidine hydrochloride

: 158214-16-5
tert-butyl 4-<3-<2-(methoxycarbonyl)-3-oxocyclopentanyl>propyl>benzoate

: 158214-23-4
tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 5h; Heating;
DOI:10.1021/jm00037a012

Reference yield:

: 65874-27-3
4-(tert-butoxycarbonyl)benzaldehyde

: 158214-23-4
tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, RT, 1 h

2: H₂ / 10percent Pd/C

3: 1N aq. NaOH / ethanol / 3 h / Ambient temperature

4: 97 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / Ambient temperature

5: 45 g / triethylamine / CH₂Cl₂ / 1 h

6: 95 percent / NaI / acetone / 12 h / Heating

7: 56 percent / tributyltin hydride, AIBN / benzene / Heating

8: 21.4 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; tri-n-butyl-tin hydride; sodium hydride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jm00037a012

Reference yield:

: 149325-50-8
ethyl 3-<4-(tert-butoxycarbonyl)phenyl>acrylate

: 158214-23-4
tert-butyl 4-<3-(2-amino-6,7-dihydro-4-oxo-5H-cyclopentapyrimidin-5-yl)propyl>benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C

2: 1N aq. NaOH / ethanol / 3 h / Ambient temperature

3: 97 percent / NaBH₄, BF₃*Et₂O / tetrahydrofuran / Ambient temperature

4: 45 g / triethylamine / CH₂Cl₂ / 1 h

5: 95 percent / NaI / acetone / 12 h / Heating

6: 56 percent / tributyltin hydride, AIBN / benzene / Heating

7: 21.4 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 5 h / Heating

With sodium hydroxide; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; tri-n-butyl-tin hydride; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetone; tert-butyl alcohol; benzene;
DOI:10.1021/jm00037a012