5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

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Chemical Name:5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt
CAS No.:1073186-84-1
Molecular Formula:C₆H₁₄N₄O₂*C₂₅H₃₆N₂O₅S₂
Molecular Weight:682.906
Hs Code.:

Synonyms:5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

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Chemical Property of 5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

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Technology Process of 5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

There total 8 articles about 5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 74-79-3,25212-18-4
L-arginine

: 1073186-72-7
5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid

: 1073186-84-1
5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

Guidance literature:: In ethanol; water; at 20 ℃; for 1.08333h;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1073186-84-1
5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16.75 h / 0 - 20 °C

2.1: caesium carbonate / butanone / 8 h / 60 °C

2.2: 16.5 h / 20 °C

2.3: 0.5 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

4.1: methanol; lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

4.2: pH 2

5.1: ethanol; water / 1.08 h / 20 °C

With methanol; lithium hydroxide; water; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; butanone;

Reference yield:

: 141699-59-4
1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate

: 1073186-84-1
5-[4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-piperidine-1-sulfonyl]-1-methyl-1H-pyrrole-2-carboxylic acid L-arginine salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / butanone / 8 h / 60 °C

1.2: 16.5 h / 20 °C

1.3: 0.5 h

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 5 h / 20 °C

3.1: methanol; lithium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

3.2: pH 2

4.1: ethanol; water / 1.08 h / 20 °C

With methanol; lithium hydroxide; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; butanone;