(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Base Information

Chemical Name:(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate
CAS No.:1371609-36-7
Molecular Formula:C₁₄H₁₂F₃N₃O₃
Molecular Weight:327.263
Hs Code.:

Synonyms:(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

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Chemical Property of (R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

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Technology Process of (R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

There total 6 articles about (R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 684-93-5
1-methyl-1-nitrosourea

: 1371609-35-6
(R)-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid

: 1371609-36-7
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(R)-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 1371609-36-7
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopentyl nitrite / acetonitrile / 0.5 h / 0 °C

1.2: 4 h / 0 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4.1: potassium hydroxide / diethyl ether

4.2: 1 h / 0 - 20 °C / Inert atmosphere

With hydrogen; caesium carbonate; potassium hydroxide; isopentyl nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; diethyl ether; acetonitrile;

Reference yield:

: 1254700-17-8
benzyl (4R)-1-methyl-2-oxo-4-imidazolidinecarboxylate

: 1371609-36-7
(R)-methyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

3.1: potassium hydroxide / diethyl ether

3.2: 1 h / 0 - 20 °C / Inert atmosphere

With hydrogen; caesium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; diethyl ether;