(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

Base Information

Chemical Name:(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate
CAS No.:1371609-33-4
Molecular Formula:C₁₇H₂₂N₂O₅
Molecular Weight:334.372
Hs Code.:

Synonyms:(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

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Chemical Property of (R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

Chemical Property:

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Technology Process of (R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

There total 2 articles about (R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1033726-49-6
benzyl 3-tert-butyloxycarbonyl-imidazolidin-2-one-4(R)-carboxylate

: 74-88-4
methyl iodide

: 1371609-33-4
(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

Guidance literature:: benzyl 3-tert-butyloxycarbonyl-imidazolidin-2-one-4(R)-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 92828-64-3
(R)-2-tert-butoxycarbonylamino-succinic acid 1-benzyl ester

: 1371609-33-4
(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / -10 °C

1.2: 2 h / -10 - 20 °C

2.1: toluene / 4 h / 80 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C

3.2: 2 h / 20 °C

With chloroformic acid ethyl ester; sodium hydride; triethylamine; In tetrahydrofuran; toluene; mineral oil;

Reference yield:

: 1371609-33-4
(R)-1-tert-butyl 5-benzyl 3-methyl-2-oxoimidazolidine-1,5-dicarboxylate

: 1371609-34-5
(R)-benzyl-3-(4-cyano-3-(trifluoromethyl)phenyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

2: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

With caesium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;