Technology Process of <3aR-<3aα,4α,5β(R),7aα>>-3a,4,5,7a-tetrahydro-4-hydroxy-5-(1-phenylethoxy)benzo-1,3-dioxol-2-one
There total 10 articles about <3aR-<3aα,4α,5β(R),7aα>>-3a,4,5,7a-tetrahydro-4-hydroxy-5-(1-phenylethoxy)benzo-1,3-dioxol-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BH3*Me2S 2.) MeOH / 1.) THF, 6h 2.) 13h (repeat process 3x)
2: pyridine / 13 h / Ambient temperature
3: 1.) LiAlH4 2.) aq. NaOH / 1.) Et2O, THF, 16h 2.) 4h
4: HBF4*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; methanol; tetrafluoroboric acid diethyl ether; sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: MeONa / methanol / 0.33 h / Ambient temperature
2: m-chloroperbenzoic acid / CH2Cl2 / 40 h / Ambient temperature
3: HBF4*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature
With
tetrafluoroboric acid diethyl ether; sodium methylate; 3-chloro-benzenecarboperoxoic acid;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) BH3*Me2S 2.) MeOH / 1.) THF, 6h 2.) 13h (repeat process 3x)
2: pyridine / 13 h / Ambient temperature
3: 1.) LiAlH4 2.) aq. NaOH / 1.) Et2O, THF, 16h 2.) 4h
4: HBF4*OEt2 / CH2Cl2 / 0.5 h / Ambient temperature
With
pyridine; methanol; tetrafluoroboric acid diethyl ether; sodium hydroxide; lithium aluminium tetrahydride; dimethylsulfide borane complex;
In
dichloromethane;
