1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone

Base Information

• Chemical Name: 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone
• CAS No.: 117023-89-9
• Molecular Formula: C₃₀H₃₃F₂NO₅
• Molecular Weight: 525.593

Synonyms:1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone

Chemical Property of 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone

There total 3 articles about 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2) + <3-methoxy-4-(oxiranylmethoxy)phenyl>ethanone (69114-02-9) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone (117023-89-9)

Guidance literature:

In ethanol; ethyl acetate; a) room temperature, 16 h, b) reflux, 3 h;

DOI:10.1021/jm00121a022

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone (117023-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 48 percent / ethanol; ethyl acetate / a) room temperature, 16 h, b) reflux, 3 h

With hydrogen; magnesium; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00121a022

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone (117023-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 48 percent / ethanol; ethyl acetate / a) room temperature, 16 h, b) reflux, 3 h

With hydrogen; magnesium; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm00121a022

upstream raw materials:

1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

<3-methoxy-4-(oxiranylmethoxy)phenyl>ethanone

N-benzyl isonipecotic acid ethyl ester

1-Bromo-4-fluorobenzene

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 117023-89-9 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-3-methoxyphenyl>ethanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send