4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

Base Information

Chemical Name:4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile
CAS No.:73735-20-3
Molecular Formula:C₂₁H₂₂FN₅
Molecular Weight:363.438
Hs Code.:

Synonyms:4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

Suppliers and Price of 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

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Technology Process of 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

There total 4 articles about 4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 107-14-2
chloroacetonitrile

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 73735-20-3
4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 73735-20-3
4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 55 percent / sodium carbonate, potassium iodide / dimethylformamide / 2 h / 60 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 73735-20-3
4-<<1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidineacetonotrile

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 55 percent / sodium carbonate, potassium iodide / dimethylformamide / 2 h / 60 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029