3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

Base Information

Chemical Name:3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester
CAS No.:122033-55-0
Molecular Formula:C₁₁H₇BrF₄O₃
Molecular Weight:343.072
Hs Code.:

Synonyms:3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

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Chemical Property of 3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

There total 2 articles about 3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1071-46-1
hydrogen ethyl malonate

: 122033-54-9
4-bromo-2,3,5,6-tetrafluorobenzoyl chloride

: 122033-55-0
3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

Guidance literature:: With n-butyllithium;
DOI:10.1021/jm00014a005

Reference yield:

: 4707-24-8
4-bromotetrafluorobenzenecarboxylic acid

: 122033-55-0
3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PCl₅

2: 86 percent / BuLi

With n-butyllithium; phosphorus pentachloride;
DOI:10.1021/jm00014a005

Reference yield:

: 122033-55-0
3-(4-Bromo-2,3,5,6-tetrafluoro-phenyl)-3-oxo-propionic acid ethyl ester

: 123942-19-8
ethyl 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-6-fluoro-4-oxo-5-<(phenylmethyl)thio>-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / Ambient temperature

2: tetrahydrofuran / 1 h

3: 62 percent / K₂CO₃ / dimethylformamide / 1.5 h / 150 °C

4: 43 percent / HMPA, PdCl₂(PPh₃)2 / tetrahydrofuran / 24 h / Heating

5: 94 percent / NaH / tetrahydrofuran

With N,N,N,N,N,N-hexamethylphosphoric triamide; bis-triphenylphosphine-palladium(II) chloride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00014a005