1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

Base Information

Chemical Name:1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol
CAS No.:1616475-60-5
Molecular Formula:C₂₀H₂₆N₄O₂
Molecular Weight:354.452
Hs Code.:

Synonyms:1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

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Chemical Property of 1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

Chemical Property:

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Technology Process of 1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

There total 7 articles about 1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: C₁₉H₂₈N₄O

: 1616475-60-5
1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

Guidance literature:: With pyridine; In dichloromethane; toluene; at 20 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

: 1616475-40-1
N¹-(5-(3-(dimethylamino)propoxy)-2-nitrophenyl)-N⁴,N⁴-dimethylbenzene-1,4-diamine

: 1616475-60-5
1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4.5 h / 20 °C / 760.05 Torr / Inert atmosphere

2: pyridine / dichloromethane; toluene / 0.08 h / 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2014.05.009

Reference yield:

: 5407-04-5
3-(dimethylamino)propyl chloride hydrochloride

: 1616475-60-5
1-(4-(dimethylamino)phenyl)-6-(3-(dimethylamino)propoxy)-1H-benzo[d]imidazol-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 60 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / acetonitrile / 21 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 4.5 h / 20 °C / 760.05 Torr / Inert atmosphere

4: pyridine / dichloromethane; toluene / 0.08 h / 20 °C / Inert atmosphere

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.bmcl.2014.05.009