Technology Process of (2R,3S)-3-(cyclopropylmethyl)-N1-((R)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide
There total 17 articles about (2R,3S)-3-(cyclopropylmethyl)-N1-((R)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C30H33F4N3O4;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1.83333h;
With
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
tetrahydrofuran; isopropyl alcohol;
at 8 - 20 ℃;
In
methanol; carbon dioxide;
at 40 ℃;
under 75007.5 Torr;
Supercritical conditions;
liquid CO2;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
1.2: 20 °C
2.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
4.2: 8 - 20 °C
4.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
With
oxalyl dichloride; hydrogen bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hexacyanoferrate(II); sodium hydrogencarbonate; sodium hydroxide / N,N-dimethyl-formamide; water / 1.67 h / 110 - 120 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1.5 h / 0 °C
2.2: 20 °C
3.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C
4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 1.5 h / 20 °C
5.1: trifluoroacetic acid / dichloromethane / 1.83 h / 20 °C
5.2: 8 - 20 °C
5.3: Lux-Cell4 / 40 °C / 75007.5 Torr / Supercritical conditions; liquid CO2
With
potassium hexacyanoferrate(II); oxalyl dichloride; hydrogen bromide; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
