(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

Base Information

• Chemical Name: (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid
• CAS No.: 1581735-04-7
• Molecular Formula: C₁₅H₂₃F₃O₄
• Molecular Weight: 324.34
• Mol file: 1581735-04-7.mol

Synonyms:(R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

Chemical Property of (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

Chemical Property:

• Boiling Point: 371.4±42.0 °C(Predicted)
• Density: 1.196±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Butanedioicacid,2-(cyclopropylmethyl)-3-(3,3,3-trifluoropropyl)-,1-(1,1-dimethylethyl)ester,(2S,3R)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid

There total 15 articles about (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate (1581734-69-1) → (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid (1581735-04-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; for 2h;

Reference yield:

(3R)-tert-butyl 2-(cyclopropylmethyl)-6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)hexanoate → (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid (1581735-04-7) + (R)-2-((R)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid (1581735-05-8)

Guidance literature:

(3R)-tert-butyl 2-(cyclopropylmethyl)-6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)hexanoate; With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 3h;

With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 20 ℃; for 0.833333h; Inert atmosphere;

With diethylaluminium chloride; In tetrahydrofuran; hexane; at -78 - 24 ℃; for 0.833333h; Overall yield = 79 %; Overall yield = 2.01 g; Inert atmosphere;

Reference yield:

(R)-2-(1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid → (R)-2-((S)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid (1581735-04-7) + (R)-2-((R)-1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid (1581735-05-8)

Guidance literature:

(R)-2-(1-tert-butoxy-3-cyclopropyl-1-oxopropan-2-yl)-5,5,5-trifluoropentanoic acid; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 24 ℃; for 0.833333h; Inert atmosphere;

With diethylaluminium chloride; In tetrahydrofuran; hexane; at -78 - 24 ℃; for 0.833333h; Overall yield = 90 %; Overall yield = 1.79 g;

upstream raw materials:

(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

t-butyl-3-(cyclopropyl)-propanoate

3-cyclopropanepropionic acid

(2S,3R)-tert-butyl 2-(cyclopropylmethyl)-6,6,6-trifluoro-3-((S)-4-isopropyl-2-oxooxazolidine-3-carbonyl)hexanoate

Downstream raw materials:

(2R,3S)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-5 trifluoropropyl)succinate

(2R,3R)-1-benzyl 4-tert-butyl 3-(cyclopropylmethyl)-2-(3,3,3-trifluoropropyl)succinate

(2R,3S)-3-(cyclopropylmethyl)-N₁-((R)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide

(2R,3S)-3-(cyclopropylmethyl)-N-((3S)-9-fluoro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide