5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

Base Information

Chemical Name:5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide
CAS No.:1403258-65-0
Molecular Formula:C₂₃H₂₈BrF₂N₃O₃
Molecular Weight:512.394
Hs Code.:

Synonyms:5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

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Chemical Property of 5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

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Technology Process of 5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

There total 8 articles about 5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403258-64-9
5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-2-methylbenzoic acid

: 1403258-65-0
5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

Guidance literature:: 5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-2-methylbenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 43.3333h;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403258-65-0
5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 7 h / 80 °C

3.1: acetic acid / 1,1-dichloroethane / 0.25 h / 20 °C

3.2: 0 - 20 °C

4.1: sodium tetrahydroborate / 4.2 h / 50 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 7 h / 50 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

6.2: 43.33 h / 0 - 20 °C

With sodium tetrahydroborate; water; iron; sodium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; 1,1-dichloroethane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1403257-49-7
2-methyl-3[(tetrahydro-2H-pyran-4-yl)amino]-5-bromobenzoic acid methyl ester

: 1403258-65-0
5-bromo-3-[(2,2-difluoroethyl)(oxan-4-yl)amino]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / 4.2 h / 50 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 7 h / 50 °C

2.2: pH 4

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

3.2: 43.33 h / 0 - 20 °C

With sodium tetrahydroborate; water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;