33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene

Base Information

• Chemical Name: 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene
• CAS No.: 84011-90-5
• Molecular Formula: C₄₄H₅₀N₆O₆
• Molecular Weight: 758.918

Synonyms:33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene

Chemical Property of 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene

Chemical Property:

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Technology Process of 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene

There total 7 articles about 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone (83604-32-4) + 2,6-Bis-bromomethyl-3'-methoxymethyl-biphenyl (84011-91-6) → 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.12,6.17,11.113,17.119,23.124,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene (84011-90-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at -78 - 25 ℃; for 40h;

DOI:10.1021/ja00339a035

Reference yield:

2,6-dinitro-4-methylanisole (29455-11-6) → 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.12,6.17,11.113,17.119,23.124,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene (84011-90-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 55 percent / ammonium sulfide 22percent / methanol / 0.67 h / Heating

2: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

3: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

4: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

5: CH₂Cl₂ / 48.5 h / slight initial warming

6: 61.8 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 15 h / 32 °C

7: 1.) sodium hydride / 1.) THF, reflux, 4 h; 2.) THF -78 deg C to rt, 40 h, 3.) MeOH, water, reflux

With pyridine; hydrogenchloride; sodium hydroxide; ammonium sulfide; potassium tert-butylate; benzyltriethylammonium bromide; iron; sodium hydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; tert-butyl alcohol; benzene;

DOI:10.1021/ja00329a059

Reference yield:

2-methoxy-3-nitro-5-methylaniline (83604-27-7) → 33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3-(methoxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.12,6.17,11.113,17.119,23.124,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene (84011-90-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 90 percent / pyridine / tetrahydrofuran / 30 h / Heating

2: 70 percent / NaOH, benzyltriethylammonium bromide / benzene; H₂O / 96 h / 46 °C

3: 97.6 percent / iron powder, hydrochloric acid / ethanol; H₂O / 3 h / Heating

4: CH₂Cl₂ / 48.5 h / slight initial warming

5: 61.8 percent / potassium tert-butoxide / 2-methyl-propan-2-ol / 15 h / 32 °C

6: 1.) sodium hydride / 1.) THF, reflux, 4 h; 2.) THF -78 deg C to rt, 40 h, 3.) MeOH, water, reflux

With pyridine; hydrogenchloride; sodium hydroxide; potassium tert-butylate; benzyltriethylammonium bromide; iron; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; water; tert-butyl alcohol; benzene;

DOI:10.1021/ja00329a059

upstream raw materials:

1,3-bis<2-methoxy-3-(1-tetrahydro-(3H)-pyrimidinonyl)-5-methylphenyl>tetrahydro-2(1H)-pyrimidinone

2,6-Bis-bromomethyl-3'-methoxymethyl-biphenyl

2,6-dinitro-4-methylanisole

2-methoxy-3-nitro-5-methylaniline

Downstream raw materials:

33,35,37-trioxo-34,38-dimethoxy-4,26-dimethyl-36-<3(hydroxymethyl)phenyl>-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24)25,27-nonaene

4-nitro-phenol

L-alanine 33,35,37-trioxo-34,38-dimethoxy-4,15,26-trimethyl-1,7,11,19,23,29-hexaazaheptacyclo<27.3.1.1^2,6.1^7,11.1^13,17.1^19,23.1^24,28>octaconta-34(2),3,5,36(13),14,16,38(24),25,27-nonaene-36-yl ester perchlorate

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