(S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

• Chemical Name: (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate
• CAS No.: 1155868-20-4
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Mol file: 1155868-20-4.mol

Synonyms:(S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property of (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 1 articles about (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate (134038-74-7) → (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (1155868-20-4)

Guidance literature:

With water;

DOI:10.1021/jo900263s

Reference yield: 69.0%

(S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (1155868-20-4) + 2-tert-butyl-2-methyl-1,3-dioxan-5-one (170876-75-2) → C23H33NO7 (1155868-23-7)

Guidance literature:

With L-proline; lithium chloride; In dimethyl sulfoxide; at 5 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo900263s

Reference yield: 58.0%

(S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate (1155868-20-4) + 2-tert-butyl-2-methyl-1,3-dioxan-5-one (170876-75-2) → C23H33NO7 + C23H33NO7 (1155868-37-3)

Guidance literature:

With D-Prolin; lithium chloride; In dimethyl sulfoxide; at 5 - 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo900263s

upstream raw materials:

benzyl (S)-5-formyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Downstream raw materials:

C₂₃H₃₃NO₇

C₂₃H₃₃NO₇

benzyl (5S)-5-[(1S,2S)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

benzyl (5S)-5-[(1R,2R)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate