134038-74-7

Usage

Uses

Used in Organic Synthesis:
3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure and chiral configuration make it a valuable building block for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)is used as a starting material or a synthetic intermediate for the development of new drugs. Its chiral (5S)configuration allows for the creation of enantiomerically pure compounds, which is essential for the discovery of drugs with improved efficacy and reduced side effects.
Used in the Production of Fine Chemicals:
3-Oxazolidinecarboxylic acid, 5-forMyl-2,2-diMethyl-, phenylMethyl ester, (5S)is also utilized in the production of fine chemicals, which are high-purity chemicals used in various applications such as fragrances, flavors, dyes, and other specialty products. Its unique structure and chiral properties contribute to the development of novel and high-quality fine chemicals.

Upstream product

• 385836-99-7 (S)-(2,2-dimethyl-5-oxo-[1,3]dioxalan-4-ylmethyl)carbamic acid benzyl ester 
• 501-53-1 benzyl chloroformate 
• 135582-87-5 (S)-methyl 3-(benzyloxycarbonylamino)-2-hydroxypropanoate 
• 42491-79-2 (2S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxypropanoic acid 
• 135582-86-4 (S)-3-benzyloxycarbonyl-2,2-dimethyl-5-o-nitrobenzoyloxymethyl-1,3-oxazolidine 
• 134038-72-5 (S)-3-benzyloxycarbonylamino-2-hydroxy-1-(o-nitrobenzoyloxy)propane 
• 134038-71-4 (S)-4-benzyloxycarbonylaminomethyl-2,2-dimethyl-1,3-dioxolane 
• 135582-93-3 (S)-3-[N-(benzyloxycarbonyl)amino]-1,2-propanediol 
• 135582-88-6 (S)-3-benzyloxycarbonyl-5-methoxycarbonyl-2,2-dimethyl-1,3-oxazolidine 
• 134038-73-6 benzyl (S)-5-hydroxymethyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 135638-41-4 (R)-3-benzyloxycarbonyl-5-<(Z)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-2,2-dimethyl-1,3-oxazolidine 
• 134038-75-8 (R)-3-benzyloxycarbonyl-5-<(E)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)vinyl>-2,2-dimethyl-1,3-oxazolidine 
• 134038-76-9 (R)-3-benzyloxycarbonyl-5-<(S)-N-tert-butoxycarbonylalanin-3-yl>-2,2-dimethyl-1,3-oxazolidine 
• 135582-94-4 (R)-3-benzyloxycarbonyl-5-<(S)-2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)ethyl>-2,2-dimethyl-1,3-oxazolidine 
• 1429470-98-3 benzyl (5R)-2,2-dimethyl-5-[(1E)-3-oxobut-1-en-1-yl]-1,3-oxazolidine-3-carboxylate 
• 1429470-99-4 benzyl (5R)-2,2-dimethyl-5-[(1Z)-3-oxobut-1-en-1-yl]-1,3-oxazolidine-3-carboxylate 
• 134038-73-6 benzyl (S)-5-hydroxymethyl-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429471-04-4 benzyl (5S)-5-[(1R,2R)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429471-03-3 benzyl (5S)-5-[(1S,2S)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429470-96-1 benzyl (5S)-5-[(1S,2R)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429470-97-2 benzyl (5S)-5-[(1R,2S)-1,2-dihydroxy-3-oxobutyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429471-00-0 benzyl (5S)-5-[(1R,2R)-1,2-dihydroxy-3-oxononyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1429471-01-1 benzyl (5S)-5-[(1S,2S)-1,2-dihydroxy-3-oxononyl]-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 1155868-20-4 (S)-benzyl 5-(dihydroxymethyl)-2,2-dimethyloxazolidine-3-carboxylate 

Relevant academic research and scientific papers

Organocatalytic syn-aldol reactions of hydroxy ketones with (S)-isoserinal: Asymmetric synthesis of 6-deoxy-1,5-iminohexitols and related compounds

An improved and convenient preparation of protected (S)-isoserinal on a large scale is reported. This key intermediate was reacted through organocatalyzed aldol reaction or Wittig based chain extension and functionalization to give enantiopure 1,5,6-trideoxy-1,5-imino-hexitols such as 10a (L-manno) and 10b (D-gluco). These two compounds are of interest as glycosidase inhibitors. The elaborated organocatalytic process includes diastereoselective syn aldol reaction of (S)-isoserinal hydrate and hydroxyacetone or 1-hydroxy-2-octanone and is promoted by various amino acid-based catalysts. Diastereoselectivities of up to 8:1 were achieved, thus establishing a new, efficient synthetic route to these important carbohydrate mimics. A novel protocol for the preparation of 1,5,6-trideoxy-1,5-imino-L- mannitol and 1,5,6-trideoxy-1,5-imino-D-glucitol is reported. The key steps include organocatalyzed syn-selective direct aldol reaction of hydroxyacetone and CBz-protected isoserinal hydrate, followed by reductive amination/ cyclization. Copyright

Organocatalytic syn-aldol reactions of dioxanones with (S)-isoserinal hydrate: Synthesis of L-deoxymannojirimycin and L-deoxyidonojirimycin

(Chemical Equation Presented) We report a new protocol for synthesis of L-1-deoxymannojirimycin, L-1-deoxyidonojirimycin, and the N-isopropyl derivative of the latter compound from the readily available precursors (S)-isoserinal hydrate and 2-tert-butyl-2

Substituted imidazole derivatives

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:

The Synthesis of Biphenomycin B

Biphenomycin B, a highly potent antibiotic against Gram-negative, β-lactam-resistant bacteria, which was previously isolated from culture filtrates of Streptomyces griseorubiginosus No. 43708, has now been synthesized.

Total synthesis of the biphenomycins; II. Synthesis of protected (2S,4R)-4-hydroxyornithines

Improved synthetic methods for the preparation of three differently protected (2S,4R)-4-hydroxyornithine (10, 16, 24) have been developed which obviously can be used for the construction of the other stereoisomers. Formation of the corresponding α,β-dideh