tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Base Information

Chemical Name:tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate
CAS No.:1428745-57-6
Molecular Formula:C₂₃H₂₉F₄N₅O₆S
Molecular Weight:579.573
Hs Code.:

Synonyms:tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

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Chemical Property of tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

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Technology Process of tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

There total 7 articles about tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 935519-74-7
(2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methanamine

: 1402586-22-4
2-(N-(2-fluoro-4-(phenoxycarbonylamino)benzyl)sulfamoyl-carbamoyloxy)-2-methylpropan-1-ylium

: 1428745-57-6
tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: With dmap; In acetonitrile; at 50 ℃;

Reference yield:

: 1427-07-2
2-fluoro-4-nitrotoluene

: 1428745-57-6
tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 24 h / Reflux

2.1: N,N-dimethyl-formamide

3.1: hydrazine hydrate / tetrahydrofuran / 6 h / Reflux

4.1: dichloromethane / 0.17 h

4.2: 0.5 h / 50 °C

4.3: 3 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6 h / 20 °C

6.1: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 20 °C

7.1: dmap / acetonitrile / 50 °C

With pyridine; dmap; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1402586-10-0
2-(2-fluoro-4-nitrobenzyl)isoindoline-1,3-dione

: 1428745-57-6
tert-butyl N-(2-fluoro-4-(3-((2-isopropoxy-6-(trifluoromethyl)pyridin-3-yl)methyl)ureido)benzyl)sulfamoylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / tetrahydrofuran / 6 h / Reflux

2.1: dichloromethane / 0.17 h

2.2: 0.5 h / 50 °C

2.3: 3 h / 20 °C

3.1: hydrogen; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 6 h / 20 °C

4.1: pyridine / tetrahydrofuran; acetonitrile / 1 h / 0 - 20 °C

5.1: dmap / acetonitrile / 50 °C

With pyridine; dmap; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;