(-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

Base Information

Chemical Name:(-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea
CAS No.:1256930-38-7
Molecular Formula:C₂₅H₂₂ClN₃O₂
Molecular Weight:431.922
Hs Code.:

Synonyms:(-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

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Chemical Property of (-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

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Technology Process of (-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

There total 2 articles about (-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1256930-07-0
1-(4-cyano-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea

: 1256930-39-8
(+)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

: 1256930-38-7
(-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: 1-(4-cyano-phenyl)-3-(4-methoxy-phenyl)-1-methyl-3-((Z)-1-phenyl-propenyl)-urea; With lithium R-(-)-N-isopropyl-1-phenylethyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -78 - 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol102155h

Reference yield:

: 1261161-72-1
(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

: 1256930-39-8
(+)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

: 1256930-38-7
(-)-1-[1-(4-chlorophenyl)-1-(4-cyanophenyl)allyl]-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: (Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea; With lithium (S)-(-)-N-isopropyl-1-phenylethylamide; In tetrahydrofuran; at -78 ℃; for 0.333333h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -78 - 20 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ol102155h