(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

Base Information

Chemical Name:(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea
CAS No.:1261161-72-1
Molecular Formula:C₂₅H₂₂ClN₃O₂
Molecular Weight:431.922
Hs Code.:

Synonyms:(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

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Technology Process of (Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

There total 4 articles about (Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 623-00-7
4-bromobenzenecarbonitrile

: 1256930-01-4
1-[(Z)-1-(4-chlorophenyl)propenyl]-1-(4-methoxyphenyl)-3-methylurea

: 1261161-72-1
(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In toluene; at 110 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol102155h

Reference yield:

: C₂₄H₂₀ClN₃O₂

: 74-88-4
methyl iodide

: 1261161-72-1
(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: C₂₄H₂₀ClN₃O₂; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol1027442

Reference yield:

: 1256930-34-3
(4-methoxy-phenyl)-(1-p-chloro-phenyl-allyl)-amine

: 40465-45-0
p-cyanophenyl isocyanate

: 1261161-72-1
(Z)-1-(1-(4-chlorophenyl)prop-1-enyl)-3-(4-cyanophenyl)-1-(4-methoxyphenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol1027442