N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine

Base Information

• Chemical Name: N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine
• CAS No.: 1310320-96-7
• Molecular Formula: C₁₂H₁₄FNO
• Molecular Weight: 207.248
• Mol file: 1310320-96-7.mol

Synonyms:N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine

Chemical Property of N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine

There total 3 articles about N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethene (74-85-1) + N-(1-(4-fluorophenyl)vinyl)acetamide (177750-13-9) → N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine (1310320-96-7)

Guidance literature:

N-(1-(4-fluorophenyl)vinyl)acetamide; With carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 0.333333h; Molecular sieve; Inert atmosphere;

ethene; In 1,2-dichloro-ethane; at 65 ℃; for 1h; under 760.051 Torr; Molecular sieve;

DOI:10.1021/ol201142v

Reference yield:

1-(4-fluorophenyl)ethanone (403-42-9) → N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine (1310320-96-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride

2.1: iron; acetic acid / toluene / 5 h / 75 °C / Inert atmosphere

3.1: carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere

3.2: 1 h / 65 °C / 760.05 Torr / Molecular sieve

With carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); hydroxylamine hydrochloride; silver trifluoromethanesulfonate; iron; acetic acid; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/ol201142v

Reference yield:

1-(4-fluorophenyl)ethanone oxime (329-79-3) → N-acetyl-1-methyl-1-(4-fluorophenyl)allylamine (1310320-96-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iron; acetic acid / toluene / 5 h / 75 °C / Inert atmosphere

2.1: carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate / 1,2-dichloro-ethane / 0.33 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 1 h / 65 °C / 760.05 Torr / Molecular sieve

With carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II); silver trifluoromethanesulfonate; iron; acetic acid; In 1,2-dichloro-ethane; toluene;

DOI:10.1021/ol201142v

upstream raw materials:

ethene

N-(1-(4-fluorophenyl)vinyl)acetamide

1-(4-fluorophenyl)ethanone oxime

1-(4-fluorophenyl)ethanone