cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone

Base Information

• Chemical Name: cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone
• CAS No.: 101927-00-8
• Molecular Formula: C₁₃H₁₅NO₄S
• Molecular Weight: 281.332
• Mol file: 101927-00-8.mol

Synonyms:cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone

Chemical Property of cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone

There total 5 articles about cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbon monoxide (201230-82-2) + N-(3-hydroxypent-4-enyl)-4-methylbenzenesulfonamide (90778-63-5) → cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone (101927-00-8)

Guidance literature:

With sodium acetate; copper dichloride; palladium dichloride; In acetic acid; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00259a024

Reference yield: 37.0%

N-(3-hydroxypent-4-enyl)-4-methylbenzenesulfonamide (90778-63-5) → cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone (101927-00-8) + [(2R,3S)-3-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acetic acid methyl ester (116699-82-2) + N-(tolylsulfonyl)-5-chloro-3-pentenylamine (116699-83-3)

Guidance literature:

With carbon monoxide; copper dichloride; palladium dichloride; In methanol; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1021/jo00259a024

Reference yield: 37.0%

carbon monoxide (201230-82-2) + N-(3-hydroxypent-4-enyl)-4-methylbenzenesulfonamide (90778-63-5) → 1-tosyl-1,2,5,6-tetrahydropyridine (57186-75-1) + cis-N-(tolylsulfonyl)-3-hydroxypyrrolidine-2-acetic acid lactone (101927-00-8) + [(2R,3S)-3-Hydroxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-yl]-acetic acid methyl ester (116699-82-2)

Guidance literature:

With copper dichloride; palladium dichloride; In methanol; for 24h; Ambient temperature;

DOI:10.1016/S0040-4039(00)88935-2

upstream raw materials:

methanol

carbon monoxide

N-(3-hydroxypent-4-enyl)-4-methylbenzenesulfonamide