[3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester

Base Information

Chemical Name:[3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester
CAS No.:875050-49-0
Molecular Formula:C17H15 I O4
Molecular Weight:410.208
Hs Code.:
European Community (EC) Number:687-549-5
Nikkaji Number:J3.098.067K
Mol file:875050-49-0.mol

Synonyms:875050-49-0;[3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester;Methyl 2-[3-formyl-4-[(2-iodophenyl)methoxy]phenyl]acetate;Benzeneacetic acid,3-formyl-4-[(2-iodophenyl)methoxy]-, methyl ester;SCHEMBL4110220;AMY4186;SKKVZQIOYBZXBO-UHFFFAOYSA-N;[3-Formyl-4-(2-iodobenzyloxy)phenyl]aceticacid methyl ester;[3-Formyl-4-(2-iodo-benzyloxy)-phenyl]-acetic acid methyl ester

Suppliers and Price of [3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of [3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester

Chemical Property:

PSA：52.60000
LogP:3.39820
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:410.00151
Heavy Atom Count:22
Complexity:374

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CC1=CC(=C(C=C1)OCC2=CC=CC=C2I)C=O

Technology Process of [3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester

There total 1 articles about [3-Formyl-4-(2-iodobenzyloxy)phenyl]acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 61874-04-2
(3-formyl-4-hydroxyphenyl)acetic acid methyl ester

: 59473-45-9
2-(chloromethyl)iodobenzene

: 875050-49-0
methyl [3-formyl-4-(2-iodobenzyloxy)phenyl]acetate

Guidance literature:: With sodium iodide; In acetonitrile; for 3h; Heating / reflux;

Reference yield:

: 875050-49-0
methyl [3-formyl-4-(2-iodobenzyloxy)phenyl]acetate

: 140462-76-6
olopatadine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / toluene / 1 h / 20 °C

1.2: 2.5 h / 20 °C

2.1: tetrabutyl-ammonium chloride; potassium carbonate / water; acetonitrile / 0.25 h / 20 °C

2.2: 24 h / 60 °C

3.1: sodium hydroxide / methanol; water / 3 h / 20 °C

3.2: 0.08 h

With tetrabutyl-ammonium chloride; potassium carbonate; sodium hydroxide; lithium hexamethyldisilazane; In methanol; water; toluene; acetonitrile; 1.1: Wittig reaction / 1.2: Wittig reaction / 2.1: Heck reaction / 2.2: Heck reaction;
DOI:10.1021/jo300925c

Reference yield:

: 875050-49-0
methyl [3-formyl-4-(2-iodobenzyloxy)phenyl]acetate

: 875050-51-4
(E)-methyl 3-[4-(dimethylamino)but-1-enyl]-4-(2-iodobenzyloxy)phenylacetate

Guidance literature:: [3-(dimethylamino)propyl]triphenylphosphonium iodide; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

methyl [3-formyl-4-(2-iodobenzyloxy)phenyl]acetate; In tetrahydrofuran; toluene; at 20 ℃; for 2.5h;

With hydrogenchloride; potassium carbonate; more than 3 stages;