diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

Base Information

Chemical Name:diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide
CAS No.:98376-08-0
Molecular Formula:C₂₃H₂₂N₂O₆S
Molecular Weight:454.503
Hs Code.:

Synonyms:diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

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Chemical Property of diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

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Technology Process of diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

There total 3 articles about diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

: 98376-07-9
diphenylmethyl(6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate

: 98376-08-0
diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

: 98393-50-1
diphenylmethyl(1S,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

Guidance literature:: With peracetic acid; In dichloromethane; at 5 ℃; for 0.5h; Yield given;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield:

: 33748-47-9
diphenylmethyl(6R,7R)-7-formamido-3-methylceph-3-em-4-carboxylate

: 98376-08-0
diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: LiOMMe, t-butyl hypochlorite / tetrahydrofuran / 0.37 h / -70 °C

2: peracetic acid / CH₂Cl₂ / 0.5 h / 5 °C

With peracetic acid; tert-butylhypochlorite; lithium methanolate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)96571-8

Reference yield:

: 49597-68-4
(6R,7R)-7-Amino-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester; hydrochloride

: 98376-08-0
diphenylmethyl(1R,6R,7S)-7-formamido-7-methoxy-3-methylceph-3-em-4-carboxylate-1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / 1.) NaHCO₃; 2.) HCO₂H / 1.) CH₂Cl₂, H₂O, 30 min; 2.) reflux, 18 h

2: LiOMMe, t-butyl hypochlorite / tetrahydrofuran / 0.37 h / -70 °C

3: peracetic acid / CH₂Cl₂ / 0.5 h / 5 °C

With peracetic acid; formic acid; tert-butylhypochlorite; lithium methanolate; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(01)96571-8