cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Base Information

Chemical Name:cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride
CAS No.:1356958-77-4
Molecular Formula:C₂₆H₂₃N₅O*ClH
Molecular Weight:457.962
Hs Code.:

Synonyms:cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Suppliers and Price of cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

There total 5 articles about cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 867160-71-2
linsitinib

: 1356958-77-4
cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Guidance literature:: With hydrogenchloride; In water;

Reference yield:

: 936901-74-5
cis-3-(1-bromo-8-chloro-imidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutanol

: 1356958-77-4
cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / isopropyl alcohol; water / 18 h / 75 - 85 °C / Sealed vessel; Industry scale

2.1: caesium carbonate / triphenylphosphine / N,N-dimethyl-formamide; water / 95 - 105 °C / Industry scale; Inert atmosphere

2.2: Industry scale; Inert atmosphere

3.1: hydrogenchloride / water

With hydrogenchloride; ammonia; caesium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 936901-73-4
3-(1-bromo-8-chloroimidazo[1,5-a]pyrazin-3-yl)cyclobutanone

: 1356958-77-4
cis-8-amino-3-(3-hydroxy-3-methyl-cyclobutyl)-1-(2-phenyl-quinolin-7-yl)-imidazo[1,5-a]pyrazin-7-ium chloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / -65 - -45 °C / Industry scale

1.2: 10 °C / Industry scale; Inert atmosphere

2.1: ammonia / isopropyl alcohol; water / 18 h / 75 - 85 °C / Sealed vessel; Industry scale

3.1: caesium carbonate / triphenylphosphine / N,N-dimethyl-formamide; water / 95 - 105 °C / Industry scale; Inert atmosphere

3.2: Industry scale; Inert atmosphere

4.1: hydrogenchloride / water

With hydrogenchloride; ammonia; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;