936901-73-4Relevant articles and documents
CYCLOALKYLIDENE CARBOXYLIC ACIDS AND DERIVATIVES AS BTK INHIBITORS
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, (2021/03/05)
The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).
Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics
Jin, Meizhong,Petronella, Brenda A.,Cooke, Andy,Kadalbajoo, Mridula,Siu, Kam W.,Kleinberg, Andrew,May, Earl W.,Gokhale, Prafulla C.,Schulz, Ryan,Kahler, Jennifer,Bittner, Mark A.,Foreman, Kenneth,Pachter, Jonathan A.,Wild, Robert,Epstein, David,Mulvihill, Mark J.
, p. 627 - 631 (2013/07/26)
This letter describes a series of small molecule inhibitors of IGF-1R with unique time-dependent binding kinetics and slow off-rates. Structure-activity and structure-kinetic relationships were elucidated and guided further optimizations within the series
Process to prepare substituted imidazopyrazine compounds
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Page/Page column 3, (2008/06/13)
A method of preparing wherein, X=Cl, Br, I, comprises the step of treating with N-chloro-, N-bromo-, or N-iodosuccinimide in a compatible solvent such as dimethylformamide (DMF) at 0-60° C. followed by halogenation.