N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol

Base Information

• Chemical Name: N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol
• CAS No.: 124400-54-0
• Molecular Formula: C₃₁H₂₈N₂O₈S
• Molecular Weight: 588.638

Synonyms:N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol

Chemical Property of N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol

There total 10 articles about N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N4-Benzoyl-N1-(phenylsulfonyl)-2-(benzyloxy)-p-benzoquinone Diimine (124400-37-9) + malonic acid dimethyl ester (108-59-8) → N5-Benzoyl-O-benzyl-N2-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol (124400-54-0)

Guidance literature:

With sodium methylate; In tetrahydrofuran; 1) -78 deg C, 12 h, 2) 0 deg C, 1 h;

DOI:10.1021/jo00291a059

Reference yield:

N-(tert-Butyloxycarbonyl)-2-amino-5-nitrophenol (124400-31-3) → N5-Benzoyl-O-benzyl-N2-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol (124400-54-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 85 percent / K₂CO₃, tetra-n-butylammonium iodide / acetone / 20 h / Heating

2: 69 percent / sodium dithionite / tetrahydrofuran; H₂O / 24 h / Heating

3: 90 percent / K₂CO₃ / tetrahydrofuran / 0.17 h / 25 °C

4: 88 percent / trifluoroacetic acid (0.25 M in CH₂Cl₂) / CH₂Cl₂ / 0.5 h / 25 °C

5: 79 percent / pyridine / tetrahydrofuran / 20 h / Heating

6: 93 percent / lead tetraacetate / CHCl₃ / 6 h / 25 °C

7: 90 percent / sodium methoxide / tetrahydrofuran / 1) -78 deg C, 12 h, 2) 0 deg C, 1 h

With pyridine; lead(IV) acetate; sodium dithionite; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform; water; acetone;

DOI:10.1021/jo00291a059

Reference yield:

N2-(tert-Butyloxycarbonyl)-O-benzyl-2,5-diaminophenol (124400-33-5) → N5-Benzoyl-O-benzyl-N2-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol (124400-54-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / K₂CO₃ / tetrahydrofuran / 0.17 h / 25 °C

2: 88 percent / trifluoroacetic acid (0.25 M in CH₂Cl₂) / CH₂Cl₂ / 0.5 h / 25 °C

3: 79 percent / pyridine / tetrahydrofuran / 20 h / Heating

4: 93 percent / lead tetraacetate / CHCl₃ / 6 h / 25 °C

5: 90 percent / sodium methoxide / tetrahydrofuran / 1) -78 deg C, 12 h, 2) 0 deg C, 1 h

With pyridine; lead(IV) acetate; sodium methylate; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1021/jo00291a059

upstream raw materials:

N⁴-Benzoyl-N¹-(phenylsulfonyl)-2-(benzyloxy)-p-benzoquinone Diimine

malonic acid dimethyl ester

N-(tert-Butyloxycarbonyl)-2-amino-5-nitrophenol

N²-(tert-Butyloxycarbonyl)-O-benzyl-2,5-diaminophenol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 124400-54-0 N⁵-Benzoyl-O-benzyl-N²-(phenylsulfonyl)-2,5-diamino-4-(1,1-bis(methoxycarbonyl)methyl)phenol

Send

Send

Metric Ton KG G Pound L ML

Send

Send