3633-17-8

Usage

Uses

Used in Pharmaceutical Industry:
6-Aminocaproic acid ethyl ester hydrochloride is used as an intermediate in the synthesis of various pharmaceuticals, particularly for the production of antifibrinolytic drugs. These drugs are essential in controlling bleeding by inhibiting the breakdown of fibrin, which is crucial for the clotting process.
Used in Chemical Research:
6-AMINOCAPRONIC ACID ETHYL ESTER HYDROCHLORIDE serves as a raw material in organic synthesis and chemical research, where its unique structure and reactivity contribute to the development of new chemical entities and the understanding of reaction mechanisms.
Used in Material Development:
6-Aminocaproic acid ethyl ester hydrochloride has potential applications in the development of new materials, where its properties may be leveraged to create innovative substances with specific characteristics for various uses.
Used in Production of Fine Chemicals:
As a building block in the production of fine chemicals, 6-aminocaproic acid ethyl ester hydrochloride plays a role in the synthesis of high-purity specialty chemicals that are used in a wide range of applications, including but not limited to pharmaceuticals, fragrances, and agrochemicals.

Upstream product

• 94704-41-3 7-ethoxy-2H 3,4,5,6-tetrahydroazepinium hydrochloride 
• 105-60-2 caprolactam 
• 13414-33-0 7-ethoxy-3,4,5,6-tetrahydro-2H-azepine 
• 60-32-2 6-aminohexanoic acid 
• 64-17-5 ethanol 

Downstream Products

• 56753-40-3 C₁₇H₂₄N₂O₅S 
• 143565-35-9 ethyl 6-(1,3-dibenzylhexahydro-2-oxo-1,3,5-triazin-5-yl)hexanoate 
• 345933-54-2 6-{[1-(5-Phenyl-isoxazol-3-yl)-meth-(Z)-ylidene]-amino}-hexanoic acid ethyl ester 
• 228110-68-7 ethyl 6-triphenylmethylaminohexanoic acid 
• 87590-33-8 N-<5-<2-(3-dimethylaminopropylcarbamoyl)-1-methyl-4-pyrrolyl>carbamoylpentyl>-2-nitro-3-hydroxy-4-methylbenzamide trifluoroacetate 
• 87590-35-0 N-<<5-<2-<2-(3-dimethylaminopropylcarbamoyl)-1-methyl-4-pyrrolyl>carbamoyl-1-methyl-4-pyrrolyl>carbamoylpentyl>>-2-nitro-3-hydroxy-4-methylbenzamide trifluoroacetate 
• 87590-28-1 3-Benzyloxy-N-(5-hydrazinocarbonyl-pentyl)-4-methyl-2-nitro-benzamide 
• 87590-37-2 6-(3-Benzyloxy-4-methyl-2-nitro-benzoylamino)-hexanoyl azide 
• 119705-74-7 ω-(N-Acryloylamino)capronsaeure-4-carbethoxyanilid 
• 1190-69-8 adipic acid ethyl ester-amide 
• 1346131-30-3 ethyl 6-(3,4-bis(tert-butoxycarbonylamino)benzamido)hexanoate 
• 56753-66-3 C₁₅H₂₀N₂O₅S 
• 74173-51-6 1-(5-oxohexylcarbamoyl)-5-fluorouracil 
• 74173-52-7 1-(5-hydroxyhexylcarbamoyl)-5-fluorouracil 

Relevant academic research and scientific papers

Modified Conjugated Diene-Based Polymer And Method Of Preparing The Same

The present invention relates to a modifier represented by Formula 1, a method of preparing the same, a modified conjugated diene-based polymer having a high modification ratio which includes a modifier-derived functional group, and a method of preparing the polymer.

Macrolactam Synthesis via Ring-Closing Alkene-Alkene Cross-Coupling Reactions

Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.

Directing Group in Decarboxylative Cross-Coupling: Copper-Catalyzed Site-Selective C-N Bond Formation from Nonactivated Aliphatic Carboxylic Acids

Copper-catalyzed directed decarboxylative amination of nonactivated aliphatic carboxylic acids is described. This intramolecular C-N bond formation reaction provides efficient access to the synthesis of pyrrolidine and piperidine derivatives as well as the modification of complex natural products. Moreover, this reaction presents excellent site-selectivity in the C-N bond formation step through the use of directing group. Our work can be considered as a big step toward controllable radical decarboxylative carbon-heteroatom cross-coupling.

Cross aldol condensation of acetaldehyde and formaldehyde in the presence of bifunctional systems

Liquid-phase cross-aldol condensation of acetaldehyde and formaldehyde in the presence of salts of various saturated and unsaturated linear amines, aromatic amines, diamines, and nitrogen bases, as well as in the presence of substituted piperazines, linear and cyclic amino acids and their derivatives, and nitrogen-containing ionic liquids, was studied. The cross-condensation products were formed in considerable amounts when amine hydrochlorides, N-benzoyl amino acids, and amino acid esters were used as catalyst. The formation of cross-condensation products is favored by increased basicity of the amino nitrogen atom in the salt and of the solvent.

Fluorescent epibatidine agonists for neuronal and muscle-type nicotinic acetylcholine receptors

Singled out: Specific high-affinity binding to and activation of nicotinic acetylcholine receptors (nAChRs) by fluorescent epibatidine (EPB) agonists is detected by fluorescence microscopy and electrophysiology (see picture). The optical and pharmacologic

AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES

Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase

Two series of novel heterobivalent tacrine derivatives were synthesized. A trimethoxy substituted benzene was linked to the tacrine moiety by a hydrazide-based linker. The compounds were evaluated as cholinesterase inhibitors, and trimethoxybenzoic acid derivatives with 11- or 12-atom spacers were the most potent inhibitors of human acetylcholinesterase. The inhibitors showed a surprising selectivity toward human butyrylcholinesterase, where several trimethoxyphenylpropionic acid derivatives had IC50 values less than 250 pM.

Synthesis and evaluation of oligo-1,3-thiazolecarboxamide derivatives as HIV-1 reverse transcriptase inhibitors

A set of oligo-1,3-thiazolecarboxamide derivatives able to interact with the minor groove of nucleic acids was synthesized. These oligopeptides contained different numbers of thiazole units presenting dimethylaminopropyl or EDTA moieties on the C-terminus, and aminohexanoyl or EDTA moieties on the N-terminus. The inhibition of such compounds on HIV-1 reverse transcriptase activity was evaluated using different model template-primer duplexes: DNA·DNA, RNA·DNA, DNA·RNA and RNA·RNA. The biological properties of the thiazolecarboxamide derivatives were compared to those of distamycin, another minor groove binder which contains three pyrrole rings. Similar to distamycin, the thiazole containing oligopeptides were good inhibitors of the reverse transcription reaction in the presence of DNA·DNA. But in contrast to distamycin, the oligothiazolide derivatives were able to inhibit reverse transcription in the presence of RNA·DNA or DNA·RNA template-primers. Both distamycin and oligothiazolecarboxamides had low affinity for RNA·RNA duplexes. The inhibition obtained with the newly synthesized thiazolecarboxamides showed that these compounds were more powerful and versatile inhibitors of the RT-dependent polymerization than the natural minor groove binder distamycin. (C) 2000 Elsevier Science Ltd.

Inhibition of HIV-1 integrase-catalysed reaction by new DNA minor groove ligands: The oligo-1,3-thiazolecarboxamide derivatives

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the life cycle of the retrovirus, responsible for catalysing the insertion of the viral genome into the host cell chromosome. For this reason it provides an attractive target for antiviral drug design. We synthesized a series of novel thiazole (Tz)-containing oligopeptides (TCOs; oligo-1,3-thiazolecarboxamides), specifically interacting within the minor groove of DNA. The oligocarboxamide derivatives contained 1-4 Tz rings and different N- and C-terminal groups. The effect of these oligocarboxamides on the HIV-1 IN-catalysed reaction was investigated. Some of the compounds were able to inhibit the reaction. The inhibitory effect of the TCOs increased with the number of Tz units. The structure of various additional positively and/or negatively charged groups attached to the N- and C-termini of TCOs had a pronounced effect on their interaction with the DNA substrate complexed to IN. Modified TCOs having a better affinity for this complex should provide a rationale for the design of drugs targeting the integration step. (C) 2000 Editions scientifiques et medicales Elsevier SAS.