(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

Base Information

Chemical Name:(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone
CAS No.:1451993-09-1
Molecular Formula:C₁₉H₁₇F₃N₄O₃S₂
Molecular Weight:470.496
Hs Code.:

Synonyms:(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

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Chemical Property of (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

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Technology Process of (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

There total 6 articles about (5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1452226-14-0
5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid

: 3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine trifluoroacetate

: 1451993-09-1
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

Guidance literature:: 5-amino-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidine trifluoroacetate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 106-53-6
para-bromobenzenethiol

: 1451993-09-1
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / water; acetonitrile / -78 - 20 °C

2.1: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

3.1: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

4.1: tetrabutylammonium perruthenate; sodium periodate / water; dichloromethane; acetonitrile / 0.25 h / 20 °C

5.1: dichloromethane / 1 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

6.2: 1 h / 20 °C

With sodium periodate; diethylamino-sulfur trifluoride; tetrabutylammonium perruthenate; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 4837-14-3
(4-bromophenylthio)(didifluoromethyl)sulfane

: 1451993-09-1
(5-amino-3,4-dimethylthieno[2,3-c]pyridazin-6-yl)(3-(4-((difluoromethyl)sulfonyl)phenyl)-3-fluoroazetidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / diethyl ether; hexane / 2.08 h / -78 - 20 °C / Inert atmosphere

2.1: diethylamino-sulfur trifluoride / dichloromethane / 0.25 h / 0 °C

3.1: tetrabutylammonium perruthenate; sodium periodate / water; dichloromethane; acetonitrile / 0.25 h / 20 °C

4.1: dichloromethane / 1 h / 20 °C

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 1 h / 20 °C

With sodium periodate; diethylamino-sulfur trifluoride; tetrabutylammonium perruthenate; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; HATU; In diethyl ether; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;