[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

Base Information

Chemical Name:[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester
CAS No.:252980-36-2
Molecular Formula:C₃₁H₄₈N₃O₆P
Molecular Weight:589.712
Hs Code.:

[4-(2,3-bis-<i>tert</i>-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid <i>tert</i>-butyl ester

Synonyms:[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

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Chemical Property of [4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

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Technology Process of [4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

There total 8 articles about [4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 174809-61-1
(S)-N,N'-di(tert-butoxycarbonyl)-1,2-diamino-(4-iodophenyl)propane

: 252980-35-1
tert-butyl (4-N,N-dimethylamino)phenylphosphinate

: 252980-36-2
[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

Guidance literature:: With triethylamine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In acetonitrile;
DOI:10.1016/S0040-4039(99)01579-8

Reference yield:

: 29972-74-5
(4-dimethylamino-phenyl)-phosphonous acid dichloride

: 252980-36-2
[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.60 g / CH₂Cl₂ / 1 h / 20 °C

2: 53 percent / Pd₂(dba)3; Et₃N; PPh₃ / acetonitrile / 36 h / 90 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; triphenylphosphine; In dichloromethane; acetonitrile; 1: Substitution / 2: Condensation;
DOI:10.1021/jo991246t

Reference yield:

: 121-69-7,77733-26-7
N,N-dimethyl-aniline

: 252980-36-2
[4-(2,3-bis-tert-butoxycarbonylamino-propyl)-phenyl]-(4-dimethylamino-phenyl)-phosphinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₃; pyridine / 4 h / 115 °C

2: 1.60 g / CH₂Cl₂ / 1 h / 20 °C

3: 53 percent / Pd₂(dba)3; Et₃N; PPh₃ / acetonitrile / 36 h / 90 °C

With pyridine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; triphenylphosphine; phosphorus trichloride; In dichloromethane; acetonitrile; 1: Substitution / 2: Substitution / 3: Condensation;
DOI:10.1021/jo991246t