1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

Base Information

Chemical Name:1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde
CAS No.:1351815-41-2
Molecular Formula:C₃₀H₃₁NO₄
Molecular Weight:469.58
Hs Code.:

Synonyms:1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

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Chemical Property of 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

Chemical Property:

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Technology Process of 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

There total 8 articles about 1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1351815-40-1
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

: 1351815-41-2
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; at 20 ℃; for 1.5h; Molecular sieve;

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-41-2
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 36 h / 20 °C

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Molecular sieve

With methanol; tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In dichloromethane;

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 1351815-41-2
1-{[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidine-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / 1 h / 55 °C

2.1: trifluorormethanesulfonic acid / toluene / 2.5 h / 20 °C / Cooling with ice

2.2: 18 h / 20 °C

3.1: potassium carbonate / acetonitrile / 42 h / 75 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

4.2: 0.5 h

5.1: potassium hydroxide; methanol / 20 h / 75 °C

5.2: 0.5 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 36 h / 20 °C

7.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Molecular sieve

With methanol; tetrapropylammonium perruthennate; trifluorormethanesulfonic acid; potassium tert-butylate; potassium carbonate; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; dmap; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;