[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

Base Information

Chemical Name:[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone
CAS No.:1351815-40-1
Molecular Formula:C₃₀H₃₃NO₄
Molecular Weight:471.596
Hs Code.:

Synonyms:[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

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Chemical Property of [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

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Technology Process of [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

There total 7 articles about [2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 6457-49-4
4-piperidinemethanol

: 912545-09-6
2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)benzoic acid

: 1351815-40-1
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 36h;

Reference yield:

: 912545-08-5
2,4-bis-benzyloxy-5-isopropenyl-benzoic acid methyl ester

: 1351815-40-1
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; methanol / 20 h / 75 °C

1.2: 0.5 h / 20 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 36 h / 20 °C

With methanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; In dichloromethane;

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 1351815-40-1
[2,4-bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl][4-(hydroxymethyl)piperidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / 1 h / 55 °C

2.1: trifluorormethanesulfonic acid / toluene / 2.5 h / 20 °C / Cooling with ice

2.2: 18 h / 20 °C

3.1: potassium carbonate / acetonitrile / 42 h / 75 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

4.2: 0.5 h

5.1: potassium hydroxide; methanol / 20 h / 75 °C

5.2: 0.5 h / 20 °C

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 36 h / 20 °C

With methanol; trifluorormethanesulfonic acid; potassium tert-butylate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; potassium hydroxide; dmap; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;