N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

Base Information

Chemical Name:N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester
CAS No.:861648-88-6
Molecular Formula:C₁₃H₁₄Cl₂N₂O₃
Molecular Weight:317.172
Hs Code.:

<i>N</i>-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

Synonyms:N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

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Chemical Property of N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

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Technology Process of N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

There total 3 articles about N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: (1-aminomethylcyclopropyl)-(3,5-dichlorophenyl)amine dihydrochloride

: 5781-53-3
monomethyl oxalyl chloride

: 861648-88-6
N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;
DOI:10.1002/ejoc.200400600

Reference yield:

: 861648-82-0
[1-(3,5-dichlorophenylamino)cyclopropyl]methanol

: 861648-88-6
N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / hydrazoic acid; DIAD; PPh₃ / 2-(3,5-dichlorophenoxy)ethanol / tetrahydrofuran; benzene / 22 h / -78 - 20 °C

2.1: NEt₃; 1,3-propanedithiol / methanol / 24 h / 20 °C

2.2: 87 percent / HCl / diethyl ether / 0 °C

3.1: 94 percent / NEt₃ / tetrahydrofuran / 3.5 h / 0 - 20 °C

With 1.3-propanedithiol; hydrogen azide; di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; 2-(3,5-dichlorophenoxy)ethanol; In tetrahydrofuran; methanol; benzene; 1.1: Mitsunobu reaction;
DOI:10.1002/ejoc.200400600

Reference yield:

: 861648-83-1
(1-azidomethylcyclopropyl)-(3,5-dichlorophenyl)amine

: 861648-88-6
N-[1-(3,5-dichloro-phenylamino)-cyclopropylmethyl]-oxalamic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NEt₃; 1,3-propanedithiol / methanol / 24 h / 20 °C

1.2: 87 percent / HCl / diethyl ether / 0 °C

2.1: 94 percent / NEt₃ / tetrahydrofuran / 3.5 h / 0 - 20 °C

With 1.3-propanedithiol; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1002/ejoc.200400600