tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate
CAS No.:1027385-33-6
Molecular Formula:C₂₃H₂₆F₂N₆O₃
Molecular Weight:472.495
Hs Code.:

Synonyms:tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

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Chemical Property of tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

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Technology Process of tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

There total 5 articles about tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951127-25-6
N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester

: 1027385-26-7
8,9-dihydro-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazine

: tert-butyl [(2R,3S,5S)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 1027385-33-6
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Guidance literature:: N-[(2R,3S)-2-(2,5-difluorophenyl)tetrahydro-5-oxo-2H-pyran-3-yl]carbamic acid 1,1-dimethylethyl ester; 8,9-dihydro-7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazine; With titanium(IV) isopropylate; In methanol; for 0.5h;

With decaborane; In methanol; for 24h;

Reference yield:

: C₁₀H₁₇N₅O₂

: tert-butyl [(2R,3S,5S)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 1027385-33-6
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / 80 °C

2: hydrogenchloride / 1,4-dioxane / 2 h

3: nido-decaborane / methanol / 16 h

With hydrogenchloride; nido-decaborane; In 1,4-dioxane; methanol; ethanol;
DOI:10.1016/j.bmcl.2016.04.020

Reference yield:

: 398491-59-3
3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

: tert-butyl [(2R,3S,5S)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

: 1027385-33-6
tert-butyl [(2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-b][1,2,4]triazin-8(9H)-yl)tetrahydro-2H-pyran-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium hydroxide; hydroxylamine-O-sulfonic acid / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2: ethanol / 16 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 2 h

4: nido-decaborane / methanol / 16 h

With hydrogenchloride; nido-decaborane; potassium hydroxide; hydroxylamine-O-sulfonic acid; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.04.020