2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

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Chemical Name:2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide
CAS No.:1149380-72-2
Molecular Formula:C₁₈H₁₀F₆N₆O₂
Molecular Weight:456.307
Hs Code.:

Synonyms:2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

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Technology Process of 2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

There total 5 articles about 2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₄H₁₄N₆O

: 407-25-0
trifluoroacetic anhydride

: 1149380-72-2
2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

Guidance literature:: dmap; In tetrahydrofuran; for 12h; Heating / reflux;

Reference yield:

: 6136-68-1
3-acethylbenzonitrile

: 1149380-72-2
2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / diethyl ether / 4 h / 0 - 20 °C

2: ethanol / 10 h / Reflux

3: methanol / 0.5 h / 125 °C / microwave irradiation

4: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux

5: dmap / tetrahydrofuran / 12 h / Reflux

With hydroxylamine hydrochloride; bromine; triethylamine; dmap; In tetrahydrofuran; methanol; diethyl ether; ethanol;

Reference yield:

: 50916-55-7
3-(2-bromoacetyl)benzonitrile

: 1149380-72-2
2,2,2-trifluoro-N-methyl-N-(2-(3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)imidazo[1 ,2-b]pyridazin-6-yl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 10 h / Reflux

2: methanol / 0.5 h / 125 °C / microwave irradiation

3: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux

4: dmap / tetrahydrofuran / 12 h / Reflux

With hydroxylamine hydrochloride; triethylamine; dmap; In tetrahydrofuran; methanol; ethanol;