(S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate

Base Information

• Chemical Name: (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate
• CAS No.: 1228022-16-9
• Molecular Formula: C₂₄H₂₇FN₄O₂
• Molecular Weight: 422.502
• Mol file: 1228022-16-9.mol

Synonyms:(S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate

Chemical Property of (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate

There total 1 articles about (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-chloro-4-(4-fluorophenyl)-1-phthalazine (155937-28-3) + (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester (169447-70-5) → (S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate (1228022-16-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 25 - 102 ℃; for 57h; Product distribution / selectivity;

Reference yield:

(S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate (1228022-16-9) → (S)-1-(4-fluorophenyl)-4-(3-methylpiperazin-1-yl)phthalazine (1228022-35-2)

Guidance literature:

With methanol; acetic acid; at 0 - 15 ℃; Product distribution / selectivity;

Reference yield:

(S)-tert-butyl 4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxylate (1228022-16-9) → (S)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxamide hydrochloride (1228021-18-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; methanol / 0 - 15 °C

2: dichloromethane / 72 h / 20 °C

3: hydrogenchloride / dichloromethane; diethyl ether; methanol

With hydrogenchloride; methanol; acetic acid; In methanol; diethyl ether; dichloromethane;

upstream raw materials:

1-chloro-4-(4-fluorophenyl)-1-phthalazine

(S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

(S)-1-(4-fluorophenyl)-4-(3-methylpiperazin-1-yl)phthalazine

(S)-N-(4-Fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxamide hydrochloride

(S)-N-(4-fluorophenyl)-4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methylpiperazine-1-carboxamide