2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide

Base Information

Chemical Name:2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide
CAS No.:723731-91-7
Molecular Formula:C₂₂H₃₁N₅O₂
Molecular Weight:397.52
Hs Code.:
UNII:2L5SGH4CVS
Nikkaji Number:J873.205A
ChEMBL ID:CHEMBL329160

Synonyms:2L5SGH4CVS;RS-97078 free base;UNII-2L5SGH4CVS;CHEMBL329160;2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide;3-Pyridinecarboxamide, 2-((3-(4-(2-methoxyphenyl)-1-piperazinyl)propyl)amino)-N,N-dimethyl-;723731-91-7;2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide;SCHEMBL9027734;MNIPVWNHCWNYRB-UHFFFAOYSA-N;BDBM50408229;L001538;N,N-Dimethyl-2-[3-[4-(2-methoxyphenyl)piperazino]propylamino]nicotinamide

Suppliers and Price of 2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:397.24777525
Heavy Atom Count:29
Complexity:496

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)C(=O)C1=C(N=CC=C1)NCCCN2CCN(CC2)C3=CC=CC=C3OC

Technology Process of 2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide

There total 5 articles about 2-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propylamino)-N,N-dimethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 723731-91-7
2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; H₂O / 3 h / Ambient temperature

2: K₂CO₃ / xylene / 20 h / Heating

With potassium carbonate; In tetrahydrofuran; water; xylene;
DOI:10.1021/jm970166j

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 723731-91-7
2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2, DMF / CH₂Cl₂ / 4 h / Heating

2: tetrahydrofuran; H₂O / 3 h / Ambient temperature

3: K₂CO₃ / xylene / 20 h / Heating

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; xylene;
DOI:10.1021/jm970166j

Reference yield:

: 35386-24-4
1-(2-Methoxyphenyl)piperazine

: 723731-91-7
2-{3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino}-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 4 h / 90 °C

2: N₂H₄*H₂O / ethanol / 3 h / Heating

3: K₂CO₃ / xylene / 20 h / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; xylene;
DOI:10.1021/jm970166j