[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

Base Information

Chemical Name:[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester
CAS No.:857062-31-8
Molecular Formula:C₂₈H₃₀ClNO₄Si
Molecular Weight:508.089
Hs Code.:

[3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

Synonyms:[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

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Chemical Property of [3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

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Technology Process of [3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

There total 2 articles about [3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027222-64-5
[2-bromo-3-(tert-butyl-dimethyl-silanyloxy)-benzofuran-6-yl]-carbamic acid benzyl ester

: 1679-18-1
4-Chlorophenylboronic acid

: 857062-31-8
[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 95 ℃;
DOI:10.1002/ejoc.200400891

Reference yield:

: 857062-59-0
benzyl-(3-oxo-2,3-dihydro-1-benzofuran-6-yl)carbamate

: 857062-31-8
[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / Br₂ / diethyl ether; dioxane

2: Et₃N / toluene

3: Na₂CO₃ / Pd(PPh₃)4 / toluene / 95 °C

With bromine; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; diethyl ether; toluene; 3: Suzuki reaction;
DOI:10.1002/ejoc.200400891

Reference yield:

: 857062-31-8
[3-(tert-butyl-dimethyl-silanyloxy)-2-(4-chloro-phenyl)-benzofuran-6-yl]-carbamic acid benzyl ester

: [(R)-2-(4-Chloro-phenyl)-3-oxo-2-((R)-3-oxo-1-phenyl-propyl)-2,3-dihydro-benzofuran-6-yl]-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA

2: NaOMe / methanol

With sodium methylate; trifluoroacetic acid; In methanol; 2: Michael reaction;
DOI:10.1002/ejoc.200400891