3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

• Chemical Name: 3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol
• CAS No.: 1146681-54-0
• Molecular Formula: C₂₄H₃₀F₂N₆O₂
• Molecular Weight: 472.538

Synonyms:3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Chemical Property of 3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Chemical Property:

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Technology Process of 3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 1 articles about 3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.3%

2-(2,4-difluorophenyl)-3-(4-(3-(4-nitrophenoxy)propyl)piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-47-1) → 3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-54-0)

Guidance literature:

With water; nickel; hydrazine; In ethanol; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2009.05.018

Reference yield: 90.9%

3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-54-0) + benzoyl chloride (98-88-4) → 3-(4-(3-(4-benzamidophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-57-3)

Guidance literature:

With triethylamine; In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.ejmech.2009.05.018

Reference yield:

3-(4-(3-(4-aminophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-54-0) + acetyl chloride (75-36-5) → 2-(2,4-difluorophenyl)-3-(4-(3-(4-acetamidophenoxy)propyl)piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol (1146681-58-4)

Guidance literature:

With triethylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2009.05.018

upstream raw materials:

2-(2,4-difluorophenyl)-3-(4-(3-(4-nitrophenoxy)propyl)piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

Downstream raw materials:

3-(4-(3-(4-benzamidophenoxy)propyl)piperazin-1-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

2-(2,4-difluorophenyl)-3-(4-(3-(4-acetamidophenoxy)propyl)piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

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