O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

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Chemical Name:O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide
CAS No.:1268157-68-1
Molecular Formula:C₅₀H₅₅N₄O₈P
Molecular Weight:870.982
Hs Code.:

Synonyms:O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

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Chemical Property of O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

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Technology Process of O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

There total 10 articles about O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1268157-64-7
1-[2-(1-aminocyclohexyl)ethyl]tetrahydropyrimidin-2(1H)-one

: 1268157-63-6
O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine

: 1268157-68-1
O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

Guidance literature:: With benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; at 25 ℃; for 24h; Inert atmosphere;
DOI:10.1021/jm101478n

Reference yield:

: 1268157-73-8
1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

: 1268157-68-1
O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / dichloromethane; water / 12 h / 25 °C

2: benzotriazol-1-ol; diisopropyl-carbodiimide / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With potassium carbonate; benzotriazol-1-ol; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm101478n

Reference yield:

: 886362-50-1
1-(2-amino-ethyl)-N-Boc-cyclohexylamine

: 1268157-68-1
O-[bis(benzyloxy)phosphoryl]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N'-{1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexyl}-L-tyrosinamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 25 °C / Molecular sieve; Inert atmosphere

2: 20% palladium hydroxide on carbon; hydrogen / methanol / 48 h / 20 °C / 2327.23 - 2585.81 Torr

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere

4: dichloromethane / 1.5 h / Inert atmosphere

5: potassium carbonate / dichloromethane; water / 12 h / 25 °C

6: benzotriazol-1-ol; diisopropyl-carbodiimide / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere

With 20% palladium hydroxide on carbon; hydrogen; sodium cyanoborohydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; diisopropyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm101478n