1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

Base Information

Chemical Name:1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate
CAS No.:1268157-73-8
Molecular Formula:C₂HF₃O₂*C₁₂H₂₃N₃O
Molecular Weight:339.358
Hs Code.:

Synonyms:1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

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Chemical Property of 1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

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Technology Process of 1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

There total 4 articles about 1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1268157-72-7
tert-butyl 1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexylcarbamate

: 76-05-1
trifluoroacetic acid

: 1268157-73-8
1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

Guidance literature:: In dichloromethane; for 1.5h; Inert atmosphere;
DOI:10.1021/jm101478n

Reference yield:

: 886362-50-1
1-(2-amino-ethyl)-N-Boc-cyclohexylamine

: 1268157-73-8
1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 25 °C / Molecular sieve; Inert atmosphere

2: 20% palladium hydroxide on carbon; hydrogen / methanol / 48 h / 20 °C / 2327.23 - 2585.81 Torr

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere

4: dichloromethane / 1.5 h / Inert atmosphere

With 20% palladium hydroxide on carbon; hydrogen; sodium cyanoborohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm101478n

Reference yield:

: 1268157-71-6
tert-butyl 1-{2-[(3-aminopropyl)amino]ethyl}cyclohexylcarbamate

: 1268157-73-8
1-[2-(2-oxotetrahydropyrimidin-1(2H)-yl)ethyl]cyclohexanaminium trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 48 h / 70 °C / Inert atmosphere

2: dichloromethane / 1.5 h / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101478n